For research use only. Not for therapeutic Use.
Streptozocin（Cat No.:I013934）is a naturally occurring antibiotic derived from Streptomyces achromogenes, primarily used in the treatment of pancreatic cancer, particularly insulinomas. It functions as an alkylating agent, damaging DNA by adding methyl groups to guanine bases, which leads to DNA cross-linking and cell death. Streptozocin specifically targets insulin-producing beta cells in the pancreas, which is why it is effective in treating insulinomas. However, its use is limited by its nephrotoxicity and potential for causing severe side effects, including renal damage. It is typically administered intravenously under careful medical supervision.
| Catalog Number | I013934 |
| CAS Number | 18883-66-4 |
| Molecular Formula | C₈H₁₅N₃O₇ |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | DMSO: ≥ 30 mg/mL; H2O: 113.3 mg/mL (Need ultrasonic and warming) |
| IUPAC Name | 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea |
| InChI | InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1 |
| InChIKey | ZSJLQEPLLKMAKR-GKHCUFPYSA-N |
| SMILES | CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O |
| Reference | [1]. Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.<br><br>[2]. Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.<br><br>[3]. Acer S, et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):222-5. |
