For research use only. Not for therapeutic Use.
Streptozocin is a potent DNA-methylating agent, with IC50 values of 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells respectively.
| Catalog Number | I013934 |
| CAS Number | 18883-66-4 |
| Molecular Formula | C₈H₁₅N₃O₇ |
| Purity | ≥95% |
| Target | DNA/RNA Synthesis DNA Alkylator/Crosslinker |
| Solubility | DMSO: ≥ 30 mg/mL; H2O: 113.3 mg/mL (Need ultrasonic and warming) |
| IUPAC Name | 1-methyl-1-nitroso-3-[(2S,4S,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea |
| InChI | InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3?,4?,5-,6+,7+/m1/s1 |
| InChIKey | ZSJLQEPLLKMAKR-FEQHFJGESA-N |
| SMILES | CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O |
| Reference | [1]. Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.<br><br>[2]. Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.<br><br>[3]. Acer S, et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):222-5. |
