Streptozotocin

• CAT Number: A000342
• CAS Number: 18883-66-4
• Molecular Formula: C8H15N3O7
• Molecular Weight: 265.20
• Purity: ≥95%
• Synonyms: 18883-66-4; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; AC1L1K1N; Streptozotocin (U-9889)
• Target: Apoptosis Inducers
• Solubility: >10.3mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
• InChI: InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
• InChIKey: ZSJLQEPLLKMAKR-GKHCUFPYSA-N
• SMILES: CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

Streptozotocin（Cat No.:A000342）is a nitrosourea compound derived from Streptomyces achromogenes, widely used in biomedical research and cancer therapy. It selectively targets insulin-producing beta cells in the pancreas, inducing diabetes in animal models for diabetes research. Streptozotocin’s mechanism involves DNA alkylation, leading to cell death, and its affinity for glucose transporters facilitates selective uptake by beta cells. Clinically, it is used to treat metastatic pancreatic islet cell carcinoma. Its dual role in inducing experimental diabetes and treating cancer makes it a valuable tool in endocrinology, oncology, and toxicology studies.

Reference

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