For research use only. Not for therapeutic Use.
STX-478 (CAT: I040765) is an orally bioavailable, CNS-penetrant, and allosteric PI3Kα inhibitor that selectively targets mutant forms of the PI3Kα enzyme commonly associated with cancer. Unlike ATP-competitive inhibitors, STX-478 binds to an allosteric site, offering high specificity for oncogenic PI3Kα mutations while sparing the wild-type enzyme, reducing off-target effects. It demonstrates robust and durable tumor regression in preclinical models, including those with brain metastases, due to its ability to penetrate the central nervous system. STX-478 is a promising candidate for precision oncology, making it a valuable tool in cancer research focused on PI3K-driven tumors.
| CAS Number | 2883540-92-7 |
| Synonyms | 1-(2-aminopyrimidin-5-yl)-3-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea |
| Molecular Formula | C16H12F5N5O2 |
| Purity | ≥95% |
| IUPAC Name | 1-(2-aminopyrimidin-5-yl)-3-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea |
| InChI | InChI=1S/C16H12F5N5O2/c1-6-9-2-7(17)3-10(18)12(9)28-11(6)13(16(19,20)21)26-15(27)25-8-4-23-14(22)24-5-8/h2-5,13H,1H3,(H2,22,23,24)(H2,25,26,27)/t13-/m1/s1 |
| InChIKey | LGPNQALKGDDVBD-CYBMUJFWSA-N |
| SMILES | CC1=C(OC2=C1C=C(C=C2F)F)C(C(F)(F)F)NC(=O)NC3=CN=C(N=C3)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
