For research use only. Not for therapeutic Use.
SU-5214(CAT: I009620) is a chemical compound known as a modulator of tyrosine kinase signal transduction. It is designed to influence the activity of tyrosine kinases, a class of enzymes involved in cellular signaling pathways. By modulating tyrosine kinase signaling, SU-5214 may impact various cellular processes, including cell growth, proliferation, and differentiation. The specific tyrosine kinases targeted and the downstream effects of SU-5214 would depend on the context and the specific signaling pathways involved.
| Catalog Number | I009620 |
| CAS Number | 186611-04-1 |
| Synonyms | SU 5214;3-(2-Methoxy-benzylidene)-1,3-dihydro-indol-2-one |
| Molecular Formula | C₁₆H₁₃NO₂ |
| Purity | ≥95% |
| Target | VEGFR |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C16H13NO2/c1-19-15-9-5-2-6-11(15)10-13-12-7-3-4-8-14(12)17-16(13)18/h2-10H,1H3,(H,17,18)/b13-10- |
| InChIKey | NEQZEVOPIKSAJP-RAXLEYEMSA-N |
| SMILES | O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=CC=C3OC |
| Reference | </br>1: Silva JC, Cornillot E, McCracken C, Usmani-Brown S, Dwivedi A, Ifeonu OO, Crabtree J, Gotia HT, Virji AZ, Reynes C, Colinge J, Kumar V, Lawres L, Pazzi JE, Pablo JV, Hung C, Brancato J, Kumari P, Orvis J, Tretina K, Chibucos M, Ott S, Sadzewicz L, Sengamalay N, Shetty AC, Su Q, Tallon L, Fraser CM, Frutos R, Molina DM, Krause PJ, Ben Mamoun C. Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions. Sci Rep. 2016 Oct 18;6:35284. doi: 10.1038/srep35284. PubMed PMID: 27752055; PubMed Central PMCID: PMC5082761.</br>2:Dorobisz T, Dorobisz K, Chabowski M, Pawłowski W, Janczak D, Patrzałek D, Janczak D. Incidental gallbladder cancer after cholecystectomy: 1990 to 2014. Onco Targets Ther. 2016 Aug 8;9:4913-6. doi: 10.2147/OTT.S106580. PubMed PMID: 27540304; PubMed Central PMCID: PMC4982486. |
