SU14813

For research use only. Not for therapeutic Use.

  • CAT Number: I004366
  • CAS Number: 627908-92-3
  • Molecular Formula: C23H27FN4O4
  • Molecular Weight: 442.48
  • Purity: ≥95%
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SU14813(Cat No.:I004366)is a small-molecule, selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), which plays a critical role in angiogenesis—the formation of new blood vessels. By inhibiting VEGFR-2, SU14813 blocks angiogenesis, thereby limiting the supply of nutrients and oxygen to tumors, which is essential for tumor growth and metastasis. It has shown promise in preclinical studies as a potential therapeutic agent in cancer treatment, particularly in solid tumors such as breast, lung, and colorectal cancers. SU14813’s anti-angiogenic effects make it a candidate for combination therapy in oncology.


Catalog Number I004366
CAS Number 627908-92-3
Synonyms

(Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Molecular Formula C23H27FN4O4
Purity ≥95%
Target PDGFR
Solubility 10 mM in DMSO
Storage Store at -20°C
IUPAC Name 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-
InChIKey CTNPALGJUAXMMC-ZDLGFXPLSA-N
SMILES CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O

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