Suberic Acid Bis(N-Hydroxysuccinimide Ester)

• CAT Number: R014379
• CAS Number: 68528-80-3
• Molecular Formula: C16H20N2O8
• Molecular Weight: 368.342
• Purity: ≥95%
• Synonyms: 1,1’-[(1,8-Dioxo-1,8-octanediyl)bis(oxy)]bis-2,5-pyrrolidinedione; Disuccinimidyl Suberate; NSC 340008; Octanedioic Acid di-N-Hydroxysuccinimide Ester; Suberic Acid bis(N-Hdroxy Succinimide Ester)
• Target: ADC Linker
• Storage: -20°C
• IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) octanedioate
• InChI: InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2
• InChIKey: ZWIBGKZDAWNIFC-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCCCCCC(=O)ON2C(=O)CCC2=O

Disuccinimidyl suberate (DSS) is a bifunctional cross-<wbr></wbr>linking reagent which contains two N-<wbr></wbr>hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-<wbr></wbr>permeable and is commonly used to cross-<wbr></wbr>link proteins in intact cells.