Succinate/succinate receptor antagonist 1

• CAT Number: I042294
• CAS Number: 2361972-29-2
• Molecular Formula: C17H15N3O
• Molecular Weight: 277.32
• Purity: ≥95%
• Synonyms: N-methyl-2-[4-(1,8-naphthyridin-2-yl)phenyl]acetamide
• InChI: InChI=1S/C17H15N3O/c1-18-16(21)11-12-4-6-13(7-5-12)15-9-8-14-3-2-10-19-17(14)20-15/h2-10H,11H2,1H3,(H,18,21)
• InChIKey: CNTLNLSLKYIFRS-UHFFFAOYSA-N
• SMILES: CNC(=O)CC1=CC=C(C=C1)C2=NC3=C(C=CC=N3)C=C2

Succinate/succinate receptor antagonist 1 (compound 7a) is a succinate/succinate receptor antagonist. Succinate/succinate receptor antagonist 1 blocks succinate signaling in gingival tissue. Succinate/succinate receptor antagonist 1 inhibits the activation of succinate receptor 1 (SucnRl) with an IC50 value of 20 μΜ. Succinate/succinate receptor antagonist 1 can be used for the research of periodontal disease[1].

Reference

[1]. LI, Xin, et al. PERIODONTAL DISEASE THERAPY. WO2019136022. 2020.