For research use only. Not for therapeutic Use.
Succinobucol, also known as AGI-1067; AGZ-1067, is phenolic antioxidant with anti-inflammatory and antiplatelet effects and is potentially useful for the treatment of atherosclerosis and type 2 diabetes. Succinobucol displays anti-platelet activity in rabbit and rat blood and reverses the increase in platelet aggregation in response to oxidant stress. Succinobucol induces apoptosis in vascular smooth muscle cells.
| Catalog Number | R048139 |
| CAS Number | 216167-82-7 |
| Synonyms | Butanedioic Acid 1-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] Ester; Probucol Monosuccinate; |
| Molecular Formula | C₃₅H₅₂O₅S₂ |
| Purity | ≥95% |
| Target | NF-κB |
| Storage | Store at -20°C |
| Reference | </br>1:An investigation of the antiplatelet effects of succinobucol (AGI-1067). Houston SA, Ugusman A, Gnanadesikan S, Kennedy S.Platelets. 2017 May;28(3):295-300. doi: 10.1080/09537104.2016.1218456. Epub 2016 Sep 29. PMID: 27681689 </br>2:A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer. Dan Z, Cao H, He X, Zhang Z, Zou L, Zeng L, Xu Y, Yin Q, Xu M, Zhong D, Yu H, Shen Q, Zhang P, Li Y.Theranostics. 2016 Jan 25;6(3):435-45. doi: 10.7150/thno.13896. eCollection 2016. PMID: 26909117 Free PMC Article</br>3:Succinobucol, a Non-Statin Hypocholesterolemic Drug, Prevents Premotor Symptoms and Nigrostriatal Neurodegeneration in an Experimental Model of Parkinson/’s Disease. Santos DB, Colle D, Moreira EL, Hort MA, Godoi M, Le Douaron G, Braga AL, Assreuy J, Michel PP, Prediger RD, Raisman-Vozari R, Farina M.Mol Neurobiol. 2017 Mar;54(2):1513-1530. doi: 10.1007/s12035-016-9747-z. Epub 2016 Feb 6. PMID: 26852411 </br>4:Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity. Colle D, Santos DB, Hartwig JM, Godoi M, Engel DF, de Bem AF, Braga AL, Farina M.Mol Neurobiol. 2016 Mar;53(2):1280-95. doi: 10.1007/s12035-014-9086-x. Epub 2015 Jan 27. PMID: 25619973 </br>5:Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression. Cao H, Zhang Z, Zhao S, He X, Yu H, Yin Q, Zhang Z, Gu W, Chen L, Li Y.J Control Release. 2015 May 10;205:162-71. doi: 10.1016/j.jconrel.2015.01.015. Epub 2015 Jan 15. PMID: 25598420 </br>6:Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro. Colle D, Santos DB, Hartwig JM, Godoi M, Braga AL, Farina M.Mitochondrion. 2013 Mar;13(2):125-33. doi: 10.1016/j.mito.2013.01.005. Epub 2013 Jan 17. PMID: 23333792 </br>7:Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Watt J, Kennedy S, McCormick C, Agbani EO, McPhaden A, Mullen A, Czudaj P, Behnisch B, Wadsworth RM, Oldroyd KG.Catheter Cardiovasc Interv. 2013 Mar;81(4):698-708. doi: 10.1002/ccd.24473. Epub 2012 Nov 8. PMID: 22581717 Free PMC Article</br>8:Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism. Jurček O, Lahtinen M, Wimmer Z, Drašar P, Kolehmainen E.J Pharm Sci. 2012 May;101(5):1794-802. doi: 10.1002/jps.23068. Epub 2012 Feb 9. PMID: 22323097 </br>9:Succinobucol induces apoptosis in vascular smooth muscle cells. Midwinter RG, Maghzal GJ, Dennis JM, Wu BJ, Cai H, Kapralov AA, Belikova NA, Tyurina YY, Dong LF, Khachigian L, Neuzil J, Kagan VE, Stocker R.Free Radic Biol Med. 2012 Mar 1;52(5):871-9. doi: 10.1016/j.freeradbiomed.2011.11.029. Epub 2011 Dec 21. PMID: 22203369 </br>10:Recent and emerging therapeutic medications in type 2 diabetes mellitus: incretin-based, Pramlintide, Colesevelam, SGLT2 Inhibitors, Tagatose, Succinobucol. Lo MC, Lansang MC.Am J Ther. 2013 Nov-Dec;20(6):638-53. doi: 10.1097/MJT.0b013e3181ec9eb2. Review. PMID: 20838206 |
