For research use only. Not for therapeutic Use.
Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent[1].
Sudoterb (12.5 mg/kg and 25 mg/kg, p.o., 4 and 8 weeks) is effective against M.tuberculosis in mice[2].
Sudoterb (p.o., mice) shows a LD50 of 700 mg/kg[2].
| Catalog Number | I009623 |
| CAS Number | 676266-31-2 |
| Synonyms | N-[2-methyl-5-phenyl-3-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]pyrrol-1-yl]pyridine-4-carboxamide |
| Molecular Formula | C29H28F3N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C29H28F3N5O/c1-21-24(20-35-14-16-36(17-15-35)26-9-5-8-25(19-26)29(30,31)32)18-27(22-6-3-2-4-7-22)37(21)34-28(38)23-10-12-33-13-11-23/h2-13,18-19H,14-17,20H2,1H3,(H,34,38) |
| InChIKey | PRXZOPNJRFEGRH-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(N1NC(=O)C2=CC=NC=C2)C3=CC=CC=C3)CN4CCN(CC4)C5=CC=CC(=C5)C(F)(F)F |
| Reference | [1]. Maha A. Elhakeem, et al. Synthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues. Bulletin of Faculty of Pharmacy, Cairo University. 2015, 53 (1), 45-52 [2]. Protopopova M, et al. In search of new cures for tuberculosis. Med Chem. 2007 May;3(3):301-16. |
