For research use only. Not for therapeutic Use.
Sudoxicam is a nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.
| Catalog Number | R012452 |
| CAS Number | 34042-85-8 |
| Synonyms | 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide; ?N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide;?CP 15973; NSC 615046; |
| Molecular Formula | C13H11N3O4S2 |
| Purity | ≥95% |
| Target | COX |
| Storage | -20°C |
| IUPAC Name | 4-hydroxy-2-methyl-1,1-dioxo-N-(1,3-thiazol-2-yl)-1$l^{6} |
| InChI | InChI=1S/C13H11N3O4S2/c1-16-10(12(18)15-13-14-6-7-21-13)11(17)8-4-2-3-5-9(8)22(16,19)20/h2-7,17H,1H3,(H,14,15,18) |
| InChIKey | SYCHUQUJURZQMO-UHFFFAOYSA-N |
| SMILES | CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=NC=CS3 |
| Reference | </br>1:In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Obach RS, Kalgutkar AS, Ryder TF, Walker GS.Chem Res Toxicol. 2008 Sep;21(9):1890-9. doi: 10.1021/tx800185b. Epub 2008 Aug 16. PMID: 18707140 </br>2:Metabolism of sudoxicam by the rat, dog, and monkey. Hobbs DC, Twomey TM.Drug Metab Dispos. 1977 Jan-Feb;5(1):75-81. PMID: 13979 </br>3:Interaction of sudoxicam and aspirin in animals and man. Wiseman EH, Chang YH, Hobbs DC.Clin Pharmacol Ther. 1975 Oct;18(4):441-8. PMID: 809225 </br>4:Inhibition of platelet aggregation and of experimental thrombosis by sudoxicam. Constantine JW, Purcell IM.J Pharmacol Exp Ther. 1973 Dec;187(3):653-65. No abstract available. PMID: 4770405 </br>5:Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Wiseman EH, Chiaini J.Biochem Pharmacol. 1972 Sep 1;21(17):2323-34. No abstract available. PMID: 4630489 </br>6:Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. Potent nonsteroidal antiinflammatory agents. Lombardino JG, Wiseman EH.J Med Chem. 1972 Aug;15(8):848-9. No abstract available. PMID: 4625532 |
