Sufosfamide

• CAT Number: I036766
• CAS Number: 37753-10-9
• Molecular Formula: C8H18ClN2O5PS
• Molecular Weight: 320.72
• Purity: 98%
• Synonyms: ASTA 5122; Sufosfamide
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-((3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amino)ethyl methanesulfonate
• InChI: InChI=1S/C8H18ClN2O5PS/c1-18(13,14)16-8-4-10-17(12)11(6-3-9)5-2-7-15-17/h2-8H2,1H3,(H,10,12)
• InChIKey: ZSZKJARKHWCBJK-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCNP1(=O)OCCCN1CCCl

Sufosfamide(CAT: I036766) is an alkylating agent belonging to the oxazaphosphorine class, structurally related to cyclophosphamide and ifosfamide. It exerts its anticancer effects by crosslinking DNA strands, leading to impaired DNA replication and transcription, ultimately causing apoptosis in rapidly dividing cancer cells. This mechanism makes Sufosfamide particularly valuable in the Oncology field for researching treatments of solid tumors and hematologic malignancies. Its unique metabolic activation pathway offers potential advantages in overcoming resistance associated with traditional alkylating agents. Sufosfamide is instrumental in the development of targeted chemotherapy strategies aimed at enhancing efficacy while minimizing toxicity.