Sulazepam

• CAT Number: I036770
• CAS Number: 2898-13-7
• Molecular Formula: C16H13ClN2S
• Molecular Weight: 300.80
• Purity: 98%
• Synonyms: Sulazepam; W 3676; W-3676; W3676.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2H-1,4-Benzodiazepine-2-thione, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
• InChI: InChI=1S/C16H13ClN2S/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
• InChIKey: MWGWTOPCKLQYEU-UHFFFAOYSA-N
• SMILES: S=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=NC1

Sulazepam (Cat No.: I036770) is a benzodiazepine derivative with sedative, anxiolytic, and muscle relaxant properties. It acts on the central nervous system by enhancing the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, leading to a calming effect. Sulazepam is metabolized into active compounds, including diazepam, contributing to its pharmacological activity. It has been investigated for its potential in treating anxiety disorders and insomnia. However, its clinical use is limited compared to other benzodiazepines due to metabolic considerations and alternative available treatments.

Reference

1: Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr., Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4. PubMed PMID: 29042451; PubMed Central PMCID: PMC5888400.
2: Golovenko NIa, Zin’kovskii VG. [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]. Biull Eksp Biol Med. 1976 Sep;82(9):1078-81. Russian. PubMed PMID: 11012.