For research use only. Not for therapeutic Use.
Sulcardine sulfate is a multi-ion channel blocker potentially for the treatment of arrhythmia.
| Catalog Number | I009641 |
| CAS Number | 343935-61-5 (Sulcardine sulfate) |
| Synonyms | B-87823; HBI-3000; B87823; HBI3000; B 87823; HBI 3000;N-(4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)benzyl)-4-methoxybenzenesulfonamide sulfate |
| Molecular Formula | C24H35N3O8S2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C24H33N3O4S.H2O4S/c1-31-22-6-8-23(9-7-22)32(29,30)25-16-19-14-20(17-26-10-2-3-11-26)24(28)21(15-19)18-27-12-4-5-13-27;1-5(2,3)4/h6-9,14-15,25,28H,2-5,10-13,16-18H2,1H3;(H2,1,2,3,4) |
| InChIKey | BQCSIJGCWZAHPG-UHFFFAOYSA-N |
| SMILES | O=S(C1=CC=C(OC)C=C1)(NCC2=CC(CN3CCCC3)=C(O)C(CN4CCCC4)=C2)=O.O=S(O)(O)=O |
| Reference | </br>1:Pharmacokinetics, safety, and tolerability of sulcardine sulfate: an open-label, single-dose, randomized study in healthy Chinese subjects. Chen Q, Qian HJ, Wang W, Zhang MQ, Lu DY, Lu C, Jin JM, Hu CY, Liu GY, Jia JY, Zheng HC, Li XN, Yu C, Wang YP, Liu Y.Fundam Clin Pharmacol. 2017 Feb;31(1):120-125. doi: 10.1111/fcp.12242. Epub 2016 Oct 5. PMID: 27599871 </br>2:Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study. Wang W, Qian HJ, Xin L, Zhang MQ, Lu DY, Jin JM, Liu GY, Jia JY, Zheng HC, Yu C, Wang YP, Zhu F, Liu Y.Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] PMID: 27550655 </br>3:Oral Bioavailability and Mass Balance Studies of a Novel Anti-arrhythmic Agent Sulcardine Sulfate in Sprague-Dawley Rats and Beagle Dogs. Lu YL, Li SJ, Liu GY, Li XC, Yang D, Jia JY, Zhang MQ, Zheng HC, Yu C, Zhu F, Wang YP.Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):453-459. doi: 10.1007/s13318-016-0360-3. PMID: 27402487 </br>4:Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study. Jia J, Liu G, Zhang M, Lu Y, Lu C, Liu Y, Zheng H, Wang W, Gui Y, Yu C, Li S, Wang Y.Biomed Chromatogr. 2016 Aug;30(8):1291-6. doi: 10.1002/bmc.3681. Epub 2016 Feb 8. PMID: 26715470 |
