Sulcotrione

• CAT Number: R031765
• CAS Number: 99105-77-8
• Molecular Formula: C14H13ClO5S
• Molecular Weight: 328.77
• Purity: ≥95%
• Synonyms: 2-(2-chloro-4-methylsulfonylbenzoyl)cyclohexane-1,3-dione
• InChI: InChI=1S/C14H13ClO5S/c1-21(19,20)8-5-6-9(10(15)7-8)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3
• InChIKey: PQTBTIFWAXVEPB-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)C2C(=O)CCCC2=O)Cl

Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).
The results show that sulcotrione behaves as time-independent reversible inhibitor. Similar results are previously described for natural β-triketones, and for the synthetic β-triketone NTBC. However it is the first time that such behavior is observed using a purified hydroxyphenylpyruvate dioxygenase (HPPD) and a synthetic β-triketone, namely sulcotrione. Inhibition kinetic analysis, performing with 3 hydroxyphenylpyruvate (HPP) and sulcotrione concentrations, show that the apparent KM increasing with sulcotrione concentration. This behavior is consistent with the data present in the literature, describing sulcotrione as a competitive inhibitor of HPPD[1].

Reference

[1]. Rocaboy-Faquet E, et al. A novel amperometric biosensor for ß-triketone herbicides based on hydroxyphenylpyruvatedioxygenase inhibition: A case study for sulcotrione. Talanta. 2016;146:510-6.
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