Sulfadoxine

• CAT Number: A000445
• CAS Number: 2447-57-6
• Molecular Formula: C12H14N4O4S
• Molecular Weight: 310.30
• Purity: ≥95%
• Synonyms: 2447-57-6; Sulforthomidine; Sulphadoxine; Fanasil; Sulphormethoxine
• Target: Metabolic Enzyme/Protease
• Storage: -20°C
• IUPAC Name: 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
• InChI: InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
• InChIKey: PJSFRIWCGOHTNF-UHFFFAOYSA-N
• SMILES: COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N

Sulfadoxine（Cat No.:A000445）is a long-acting sulfonamide antibiotic primarily used in combination therapies to treat malaria and certain bacterial infections. By inhibiting dihydropteroate synthase, it disrupts folate synthesis in microorganisms, a critical pathway for their growth and replication. When paired with pyrimethamine, it forms a potent antimalarial regimen effective against Plasmodium species. Sulfadoxine’s extended half-life allows for simplified dosing schedules, enhancing treatment adherence. It is also utilized in prophylactic regimens for malaria in endemic regions. Its efficacy and broad application make it a valuable tool in infectious disease management.

Reference

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