Sulfamethazine

For research use only. Not for therapeutic Use.

  • CAT Number: I004151
  • CAS Number: 57-68-1
  • Molecular Formula: C12H14N4O2S
  • Molecular Weight: 278.33
  • Purity: ≥95%
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Sulfamethazine(Cat No.:I004151)is a sulfonamide antibiotic commonly used in veterinary medicine to treat bacterial infections in livestock, particularly respiratory, urinary, and gastrointestinal infections. It works by inhibiting bacterial folic acid synthesis, which is essential for DNA and RNA production, ultimately halting bacterial growth. Sulfamethazine is favored for its broad-spectrum activity against gram-positive and gram-negative bacteria. Its long half-life allows for sustained action, making it suitable for managing infections in large animals. Additionally, it serves as a model in antimicrobial resistance research, emphasizing its importance in animal health management and pharmacology.


Catalog Number I004151
CAS Number 57-68-1
Synonyms

NSC 67457;NSC 683529;Sulfadimethyldiazine;Sulfadimidine

Molecular Formula C12H14N4O2S
Purity ≥95%
Target Bacterial
Solubility DMSO 55 mg/mL; Water <1 mg/mL
Storage 2-8°C
IUPAC Name 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
InChI InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChIKey ASWVTGNCAZCNNR-UHFFFAOYSA-N
SMILES CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C
Reference

</br>1:Combination of the Electro/Fe<sup>3+</sup>/peroxydisulfate (PDS) process with activated sludge culture for the degradation of sulfamethazine. Ledjeri A, Yahiaoui I, Kadji H, Aissani-Benissad F, Amrane A, Fourcade F.Environ Toxicol Pharmacol. 2017 May 1;53:34-39. doi: 10.1016/j.etap.2017.04.022. [Epub ahead of print] PMID: 28501782 </br>2:Biodegradation of sulfamethazine by an isolated thermophile-Geobacillus sp. S-07. Pan LJ, Tang XD, Li CX, Yu GW, Wang Y.World J Microbiol Biotechnol. 2017 May;33(5):85. doi: 10.1007/s11274-017-2245-2. Epub 2017 Apr 4. PMID: 28378223 </br>3:Uptake and translocation of sulfamethazine by alfalfa grown under hydroponic conditions. Kurwadkar S, Struckhoff G, Pugh K, Singh O.J Environ Sci (China). 2017 Mar;53:217-223. doi: 10.1016/j.jes.2016.04.019. Epub 2016 Jul 2. PMID: 28372746 </br>4:Sulfate radical-based oxidation of antibiotics sulfamethazine, sulfapyridine, sulfadiazine, sulfadimethoxine, and sulfachloropyridazine: Formation of SO<sub>2</sub> extrusion products and effects of natural organic matter. Ji Y, Shi Y, Wang L, Lu J, Ferronato C, Chovelon JM.Sci Total Environ. 2017 Sep 1;593-594:704-712. doi: 10.1016/j.scitotenv.2017.03.192. Epub 2017 Mar 28. PMID: 28363182 </br>5:Environmental behavior of sulfadiazine, sulfamethazine, and their metabolites. Biošić M, Mitrevski M, Babić S.Environ Sci Pollut Res Int. 2017 Apr;24(10):9802-9812. doi: 10.1007/s11356-017-8639-8. Epub 2017 Mar 3. PMID: 28258427 </br>6:Pyridine and 3-methylpyridine solvates of the triple sulfa drug constitutent sulfamethazine. Patel UH, Purohit KP.Acta Crystallogr C Struct Chem. 2017 Jan 1;73(Pt 1):9-12. doi: 10.1107/S2053229616015898. Epub 2017 Jan 1. PMID: 28035096 </br>7:Molecular Dynamics of Amorphous Sulfamethazine With Structurally Related Sulfonamide Impurities Evaluated Using Thermal Analysis. Hamada Y, Ono M, Ohara M, Yonemochi E.J Pharm Sci. 2017 Apr;106(4):1062-1068. doi: 10.1016/j.xphs.2016.12.008. Epub 2016 Dec 20. PMID: 28007560 </br>8:Sulfamethazine removal by means of a combined process coupling an oxidation pretreatment and activated sludge culture – preliminary results. Saidi I, Fourcade F, Floner D, Soutrel I, Bellakhal N, Amrane A, Geneste F.Environ Technol. 2017 Jan 12:1-7. doi: 10.1080/09593330.2016.1273395. [Epub ahead of print] PMID: 27973980 </br>9:Sorption mechanisms of sulfamethazine to soil humin and its subfractions after sequential treatments. Guo X, Shen X, Zhang M, Zhang H, Chen W, Wang H, Koelmans AA, Cornelissen G, Tao S, Wang X.Environ Pollut. 2017 Feb;221:266-275. doi: 10.1016/j.envpol.2016.11.073. Epub 2016 Dec 10. PMID: 27955989 </br>10:Degradation of sulfamethazine using Fe<sub>3</sub>O<sub>4</sub>-Mn<sub>3</sub>O<sub>4</sub>/reduced graphene oxide hybrid as Fenton-like catalyst. Wan Z, Wang J.J Hazard Mater. 2017 Feb 15;324(Pt B):653-664. doi: 10.1016/j.jhazmat.2016.11.039. Epub 2016 Nov 14. PMID: 27866761

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