For research use only. Not for therapeutic Use.
Sulfamethizole（Cat No.:I001728）is a sulfonamide antibiotic primarily used to treat bacterial infections, particularly urinary tract infections. It works by inhibiting folic acid synthesis in bacteria, which is essential for bacterial growth and replication. Sulfamethizole’s specific action against certain Gram-positive and Gram-negative bacteria makes it effective in treating uncomplicated infections. Known for its rapid absorption and short half-life, it is often administered in acute cases requiring prompt treatment. Despite its effectiveness, sulfamethizole may cause side effects like hypersensitivity reactions, so it is used with caution in patients with sulfa allergies.
| Catalog Number | I001728 |
| CAS Number | 144-82-1 |
| Molecular Formula | C9H10N4O2S2 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO 55 mg/mL; Water <1 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide |
| InChI | InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13) |
| InChIKey | VACCAVUAMIDAGB-UHFFFAOYSA-N |
| SMILES | CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N |
| Reference | </br>1:Mineralization of sulfamethizole in photo-Fenton and photo-Fenton-like systems. Wu CH, Wu JT, Lin YH.Water Sci Technol. 2016;73(4):746-50. doi: 10.2166/wst.2015.554. PMID: 26901716 </br>2:Molecularly Imprinted Polymer Integrated with a Surface Acoustic Wave Technique for Detection of Sulfamethizole. Ayankojo AG, Tretjakov A, Reut J, Boroznjak R, Öpik A, Rappich J, Furchner A, Hinrichs K, Syritski V.Anal Chem. 2016 Jan 19;88(2):1476-84. doi: 10.1021/acs.analchem.5b04735. Epub 2016 Jan 7. PMID: 26704414 </br>3:Photodegradation of sulfonamide antimicrobial compounds (sulfadiazine, sulfamethizole, sulfamethoxazole and sulfathiazole) in various UV/oxidant systems. Wu JT, Wu CH, Liu CY, Huang WJ.Water Sci Technol. 2015;71(3):412-7. doi: 10.2166/wst.2015.005. PMID: 25714641 </br>4:Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone. Khanfar MA, AbuKhader MM, Alqtaishat S, Taha MO.J Mol Graph Model. 2013 May;42:39-49. doi: 10.1016/j.jmgm.2013.02.009. Epub 2013 Mar 13. PMID: 23545333 </br>5:[Colonic malacoplakia treated with sulfamethizole and trimethoprim]. Christensen M, Knuhtsen S, Knudsen E.Ugeskr Laeger. 2011 Feb 14;173(7):509-10. Danish. PMID: 21320418 </br>6:Aqueous photocatalytic oxidation of sulfamethizole. Klauson D, Krichevskaya M, Borissova M, Preis S.Environ Technol. 2010 Dec 14;31(14):1547-55. doi: 10.1080/09593331003789537. PMID: 21275251 </br>7:Removal of sulfadiazine, sulfamethizole, sulfamethoxazole, and sulfathiazole from aqueous solution by ozonation. Garoma T, Umamaheshwar SK, Mumper A.Chemosphere. 2010 May;79(8):814-20. doi: 10.1016/j.chemosphere.2010.02.060. Epub 2010 Mar 19. PMID: 20303138 </br>8:Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. Bjerrum L, Gahrn-Hansen B, Grinsted P.Scand J Prim Health Care. 2009;27(1):6-11. doi: 10.1080/02813430802535312. PMID: 18991182 Free PMC Article</br>9:[Kernicterus and sulfamethizole treatment]. Høiby N.Ugeskr Laeger. 2006 Mar 27;168(13):1349-50; author reply 1350-1. Danish. No abstract available. PMID: 16579898 </br>10:[Sulfamethizole versus pivmecillinam in urinary tract infections]. Frimodt-Møller N.Ugeskr Laeger. 2003 Nov 3;165(45):4317; author reply 4317-8. Danish. No abstract available. PMID: 14635336 |
