For research use only. Not for therapeutic Use.
Sulfamethoxazole（Cat No.:A001153）is a synthetic antibiotic in the sulfonamide class, widely used for its effectiveness against various gram-positive and gram-negative bacteria. It acts by inhibiting bacterial dihydropteroate synthase, an enzyme essential for folic acid synthesis, thereby halting bacterial growth. Commonly combined with trimethoprim, Sulfamethoxazole is essential in treating respiratory, urinary tract, and gastrointestinal infections. In research, it serves as a model to study bacterial resistance mechanisms and synergy in combination therapies. Its specificity and broad applicability make it vital for developing new approaches in antimicrobial treatments.
| Catalog Number | A001153 |
| CAS Number | 723-46-6 |
| Synonyms | NA |
| Molecular Formula | C₁₀H₁₁N₃O₃S |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | 3 years -20C powder |
| IUPAC Name | 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
| InChI | InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13) |
| InChIKey | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N |
| Reference | </br>1:Microbial population shift caused by sulfamethoxazole in engineered-Soil Aquifer Treatment (e-SAT) system. Rudrashetti AP, Jadeja NB, Gandhi D, Juwarkar AA, Sharma A, Kapley A, Pandey RA.World J Microbiol Biotechnol. 2017 Jun;33(6):121. doi: 10.1007/s11274-017-2284-8. Epub 2017 May 18. PMID: 28523623 </br>2:Trimethoprim/sulfamethoxazole versus vancomycin in the treatment of healthcare/ventilator-associated MRSA pneumonia: a case-control study. Eliakim-Raz N, Hellerman M, Yahav D, Cohen J, Margalit I, Fisher S, Zusman O, Shaked H, Bishara J.J Antimicrob Chemother. 2017 May 16. doi: 10.1093/jac/dkx153. [Epub ahead of print] No abstract available. PMID: 28510730 </br>3:Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim-sulfamethoxazole. Hegde SS, Bijol V, Jaber BL.CEN Case Rep. 2016 Nov;5(2):188-191. doi: 10.1007/s13730-016-0222-5. Epub 2016 Jun 7. PMID: 28508974 Free PMC Article</br>4:Comment on: Trimethoprim/sulfamethoxazole versus vancomycin in the treatment of healthcare/ventilator-associated MRSA pneumonia: a case-control study. White BP, Villanueva RD.J Antimicrob Chemother. 2017 May 15. doi: 10.1093/jac/dkx144. [Epub ahead of print] No abstract available. PMID: 28505374 </br>5:Impacts of solids retention time on trace organic compound attenuation and bacterial resistance to trimethoprim and sulfamethoxazole. Neyestani M, Dickenson E, McLain J, Robleto E, Rock C, Gerrity D.Chemosphere. 2017 Apr 26;182:149-158. doi: 10.1016/j.chemosphere.2017.04.121. [Epub ahead of print] PMID: 28494359 </br>6:EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FAECAL CARRIAGE RATES OF RESISTANT ISOLATES OF <i>ESCHERICHIA COLI</i> IN HIV-INFECTED ADULT PATIENTS IN LAGOS. Egwuatu CC, Iwuafor AA, Egwuatu TO, Akujobi CN, Nnachi AU, Aghanya IN, Ogunsola FT, Oduyebo OO.Afr J Infect Dis. 2016 May 1;10(2):156-163. doi: 10.21010/ajid.v10i2.12. eCollection 2016. PMID: 28480451 Free PMC Article</br>7:Intravitreal Injection of Sulfamethoxazole and Trimethoprim Associated with Dexamethasone as an Alternative Therapy for Ocular Toxoplasmosis. Souza CE, Nascimento H, Lima A, Muccioli C, Belfort R Jr.Ocul Immunol Inflamm. 2017 Apr 27:1-4. doi: 10.1080/09273948.2017.1307420. [Epub ahead of print] PMID: 28448726 </br>8:Sulfamethoxazole degradation in anaerobic sulfate-reducing bacteria sludge system. Jia Y, Khanal SK, Zhang H, Chen GH, Lu H.Water Res. 2017 Aug 1;119:12-20. doi: 10.1016/j.watres.2017.04.040. Epub 2017 Apr 17. PMID: 28433879 </br>9:Sediment and salinity effects on the bioaccumulation of sulfamethoxazole in zebrafish (Danio rerio). Chen Y, Zhou JL, Cheng L, Zheng YY, Xu J.Chemosphere. 2017 Aug;180:467-475. doi: 10.1016/j.chemosphere.2017.04.055. Epub 2017 Apr 14. PMID: 28431384 </br>10:Degradation of sulfamethoxazole by UV, UV/H<sub>2</sub>O<sub>2</sub> and UV/persulfate (PDS): Formation of oxidation products and effect of bicarbonate. Yang Y, Lu X, Jiang J, Ma J, Liu G, Cao Y, Liu W, Li J, Pang S, Kong X, Luo C.Water Res. 2017 Jul 1;118:196-207. doi: 10.1016/j.watres.2017.03.054. Epub 2017 Mar 28. PMID: 28431352 |
