For research use only. Not for therapeutic Use.
Sulfanilamide（Cat No.:I004407）is a synthetic antimicrobial agent that belongs to the sulfonamide class of drugs. It works by inhibiting bacterial folic acid synthesis, which is essential for bacterial growth and replication. Sulfanilamide is effective against a variety of Gram-positive and Gram-negative bacteria and was historically used to treat bacterial infections such as urinary tract infections and respiratory tract infections. Although its use has declined with the advent of more effective antibiotics, it remains an important compound in the study of bacteriostatic agents and antimicrobial resistance.
| Catalog Number | I004407 |
| CAS Number | 63-74-1 |
| Synonyms | 4-aminobenzenesulfonamide |
| Molecular Formula | C6H8N2O2S |
| Purity | ≥95% |
| Target | Bacterial; Antibiotic |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 4-aminobenzenesulfonamide |
| InChI | InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) |
| InChIKey | FDDDEECHVMSUSB-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1N)S(=O)(=O)N |
| Reference | </br>1:Pharmacokinetics of the antimicrobial drug sulfanilamide is altered in a preclinical model of vascular calcification. Brandoni A, Torres AM.Clin Exp Pharmacol Physiol. 2017 Jan 2. doi: 10.1111/1440-1681.12722. [Epub ahead of print] PMID: 28042884 </br>2:Automated Enrichment of Sulfanilamide in Milk Matrices by Utilization of Aptamer-Linked Magnetic Particles. Fischer C, Kallinich C, Klockmann S, Schrader J, Fischer M.J Agric Food Chem. 2016 Dec 7;64(48):9246-9252. Epub 2016 Nov 28. PMID: 27933990 </br>3:Peculiar behavior of starch 2,3-dialdehyde towards sulfanilamide and sulfathiazole. Keshk SM, Ramadan AM, Al-Sehemi AG, Yousef el S, Bondock S.Carbohydr Polym. 2016 Nov 5;152:624-31. doi: 10.1016/j.carbpol.2016.07.061. Epub 2016 Jul 18. PMID: 27516312 </br>4:Ag loaded WO3 nanoplates for efficient photocatalytic degradation of sulfanilamide and their bactericidal effect under visible light irradiation. Zhu W, Liu J, Yu S, Zhou Y, Yan X.J Hazard Mater. 2016 Nov 15;318:407-16. doi: 10.1016/j.jhazmat.2016.06.066. Epub 2016 Jul 1. PMID: 27450332 </br>5:Towards a molecular level understanding of the sulfanilamide-soil organic matter-interaction. Ahmed AA, Thiele-Bruhn S, Leinweber P, Kühn O.Sci Total Environ. 2016 Jul 15;559:347-55. doi: 10.1016/j.scitotenv.2016.03.136. Epub 2016 Apr 16. PMID: 27088516 </br>6:Copper-promoted circumneutral activation of H2O2 by magnetic CuFe2O4 spinel nanoparticles: Mechanism, stoichiometric efficiency, and pathway of degrading sulfanilamide. Feng Y, Liao C, Shih K.Chemosphere. 2016 Jul;154:573-82. doi: 10.1016/j.chemosphere.2016.04.019. Epub 2016 Apr 14. PMID: 27085318 </br>7:Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide. Elbadawy M, Ishihara Y, Aboubakr M, Sasaki K, Shimoda M.J Vet Med Sci. 2016 Jul 1;78(6):1025-9. doi: 10.1292/jvms.15-0601. Epub 2016 Mar 24. PMID: 27010464 Free PMC Article</br>8:Antibiotic sulfanilamide biodegradation by acclimated microbial populations. Liao X, Li B, Zou R, Xie S, Yuan B.Appl Microbiol Biotechnol. 2016 Mar;100(5):2439-47. doi: 10.1007/s00253-015-7133-9. Epub 2015 Nov 13. PMID: 26563551 </br>9:Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide. Idemudia OG, Sadimenko AP, Afolayan AJ, Hosten EC.Bioinorg Chem Appl. 2015;2015:717089. doi: 10.1155/2015/717089. Epub 2015 May 27. PMID: 26106285 Free PMC Article</br>10:Sensitive simultaneous determination of three sulfanilamide artificial sweeters by capillary electrophoresis with on-line preconcentration and contactless conductivity detection. Yang L, Zhou S, Xiao Y, Tang Y, Xie T.Food Chem. 2015 Dec 1;188:446-51. doi: 10.1016/j.foodchem.2015.04.060. Epub 2015 May 8. PMID: 26041216 |
