For research use only. Not for therapeutic Use.
Sulfaphenazole（Cat No.:I003925）is a sulfonamide antibiotic primarily used in pharmaceutical research for its ability to inhibit cytochrome P450 2C9 (CYP2C9), an enzyme involved in drug metabolism. This selective inhibition makes Sulphaphenazole a valuable tool in drug-drug interaction studies, particularly for understanding metabolic pathways. It is also used to investigate the pharmacokinetics of drugs metabolized by CYP2C9. Sulfaphenazole is commonly utilized in preclinical studies for exploring the effects of metabolic inhibition on drug efficacy, safety, and toxicity, aiding in the development of safer therapeutics.
| Catalog Number | I003925 |
| CAS Number | 526-08-9 |
| Synonyms | 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide |
| Molecular Formula | C15H14N4O2S |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide |
| InChI | InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2 |
| InChIKey | QWCJHSGMANYXCW-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N |
| Reference | </br>1:Sulfaphenazole and α-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/spice. Chimalakonda KC, James LP, Radominska-Pandya A, Moran JH.Drug Metab Lett. 2013 Mar;7(1):34-8. PMID: 24329780 Free PMC Article</br>2:Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats. Hama S, Ishihara Y, Watanabe M, Danjo S, Nakamura Y, Itoh K.Biol Pharm Bull. 2012;35(10):1849-53. PMID: 23037177 Free Article</br>3:Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa. Ishihara Y, Shimamoto N.J Pharmacol Sci. 2012;119(3):251-9. Epub 2012 Jun 28. PMID: 22785021 Free Article</br>4:A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21. Locuson CW, Alfaro JF, Zaya MJ, Billen D, White JA, Jones JP.Drug Metab Lett. 2011 Dec;5(4):253-8. PMID: 22423626 </br>5:Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size. Ishihara Y, Sekine M, Hamaguchi A, Kobayashi Y, Harayama T, Nakazawa M, Shimamoto N.J Pharmacol Sci. 2010;113(4):335-42. Epub 2010 Jul 13. PMID: 20644334 Free Article</br>6:The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment. Virdis A, Cetani F, Giannarelli C, Banti C, Ghiadoni L, Ambrogini E, Carrara D, Pinchera A, Taddei S, Bernini G, Marcocci C.J Clin Endocrinol Metab. 2010 Feb;95(2):920-7. doi: 10.1210/jc.2009-1669. Epub 2009 Dec 18. PMID: 20022989 </br>7:Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM Jr, Gottlieb RA.Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H570-9. doi: 10.1152/ajpheart.00716.2009. Epub 2009 Dec 11. PMID: 20008275 Free PMC Article</br>8:Letter by Brown and Pretorius regarding article, /effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients/. Brown NJ, Pretorius M.Circulation. 2009 Nov 10;120(19):e159; author reply e160. doi: 10.1161/CIRCULATIONAHA.109.874743. No abstract available. PMID: 19901200 Free Article</br>9:A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo. Krötz F, Hellwig N, Bürkle MA, Lehrer S, Riexinger T, Mannell H, Sohn HY, Klauss V, Pohl U.Cardiovasc Res. 2010 Feb 1;85(3):542-50. doi: 10.1093/cvr/cvp301. Epub 2009 Aug 28. PMID: 19717402 </br>10:Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients. Giannarelli C, Virdis A, De Negri F, Magagna A, Duranti E, Salvetti A, Taddei S.Circulation. 2009 Mar 31;119(12):1625-33. doi: 10.1161/CIRCULATIONAHA.108.782482. Epub 2009 Mar 16. Erratum in: Circulation. 2009 Nov 10;120(19):e161. Dosage error in article text. PMID: 19289643 Free Article |
