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599-79-1-Sulfasalazine Sulfasalazine

Sulfasalazine

For research use only. Not for therapeutic Use.

  • CAT Number: A000909
  • CAS Number: 599-79-1
  • Molecular Formula: C18H14N4O5S
  • Molecular Weight: 398.4
  • Purity: ≥95%
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Related Small Molecules: Fenbendazole     Prednisolone     (-)-Menthol    
Research Areas: Metabolic Disease Research     Oxidative Stress and Inflammation    

Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn/’s disease. It is also indicated for use in rheumatoid arthritis and used in other types of inflammatory arthritis (e.g. psoriatic arthritis) where it has a beneficial effect. It is often well tolerated compared to other DMARDs. In clinical trials for the treatment of chronic alcoholics, sulfasalazine has been found to reverse the scarring associated with liver cirrhosis.


Catalog Number A000909
CAS Number 599-79-1
Synonyms

Salazosulfapyridine; Azopyrin; Salicylazosulfapyridine; Colo-Pleon; Azulfidine

Molecular Formula C18H14N4O5S
Purity ≥95%
Target Autophagy
Storage -20°C
InChI 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,20H,(H,19,22)(H,24,25)/b21-13-
InChIKey OQANPHBRHBJGNZ-BKUYFWCQSA-N
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O
Reference

1: Sharma A, Kumar B, Singh SK, Gulati M, Vaidya Y, Sadotra M, Rathee H, Ghai D,
Malik AH, Yadav AK, Maharshi P, Bawa P, Rajesh SY, Sharma P, Pandey NK, Mohant S.
In vitro and in vivo pharmacokinetic evaluation of guar gum-Eudragit® S100 based
colon-targeted spheroids of sulfasalazine co-administered with probiotics. Curr
Drug Deliv. 2017 Dec 7. doi: 10.2174/1567201815666171207165059. [Epub ahead of
print] PubMed PMID: 29219056.

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2: Niknahad H, Heidari R, Mohammadzadeh R, Ommati MM, Khodaei F, Azarpira N,
Abdoli N, Zarei M, Asadi B, Rasti M, Shirazi Yeganeh B, Taheri V, Saeedi A,
Najibi A. Sulfasalazine induces mitochondrial dysfunction and renal injury. Ren
Fail. 2017 Nov;39(1):745-753. doi: 10.1080/0886022X.2017.1399908. PubMed PMID:
29214868.

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3: Ommati MM, Heidari R, Jamshidzadeh A, Zamiri MJ, Sun Z, Sabouri S, Wang J,
Ahmadi F, Javanmard N, Seifi K, Mousapour S, Yeganeh BS. Dual effects of
sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis
in two experimental models. Toxicol Lett. 2017 Dec 3;284:46-55. doi:
10.1016/j.toxlet.2017.11.034. [Epub ahead of print] PubMed PMID: 29197623.
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4: Lang M, Fish J, Covelli C, Schreiber BE. DRESS syndrome triple whammy:
sulfasalazine, amoxicillin and HHV-7. Br J Hosp Med (Lond). 2017 Nov
2;78(11):648-649. doi: 10.12968/hmed.2017.78.11.648. PubMed PMID: 29111803.
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5: Zhang Z, Chen J, Duan Y, Liu W, Li D, Yan Z, Yang K. Highly luminescent
nitrogen-doped carbon dots for simultaneous determination of chlortetracycline
and sulfasalazine. Luminescence. 2017 Oct 18. doi: 10.1002/bio.3416. [Epub ahead
of print] PubMed PMID: 29044942.
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6: Shin MR, Kim KJ, Kim SH, Kim SJ, Seo BI, An HJ, Roh SS. Comparative Evaluation
between Sulfasalazine Alone and in Combination with Herbal Medicine on
DSS-Induced Ulcerative Colitis Mice. Biomed Res Int. 2017;2017:6742652. doi:
10.1155/2017/6742652. Epub 2017 Sep 6. PubMed PMID: 29018816; PubMed Central
PMCID: PMC5606053.
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7: Balza E, Castellani P, Moreno PS, Piccioli P, Medra&#241;o-Fernandez I, Semino C,
Rubartelli A. Restoring microenvironmental redox and pH homeostasis inhibits
neoplastic cell growth and migration: therapeutic efficacy of esomeprazole plus
sulfasalazine on 3-MCA-induced sarcoma. Oncotarget. 2017 Jun
27;8(40):67482-67496. doi: 10.18632/oncotarget.18713. eCollection 2017 Sep 15.
PubMed PMID: 28978047; PubMed Central PMCID: PMC5620187.
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8: Zheng H, Chen M, Li Y, Wang Y, Wei L, Liao Z, Wang M, Ma F, Liao Q, Xie Z.
Modulation of Gut Microbiome Composition and Function in Experimental Colitis
Treated with Sulfasalazine. Front Microbiol. 2017 Sep 7;8:1703. doi:
10.3389/fmicb.2017.01703. eCollection 2017. PubMed PMID: 28936203; PubMed Central
PMCID: PMC5594074.

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9: Haryu S, Saito R, Jia W, Shoji T, Mano Y, Sato A, Kanamori M, Sonoda Y,
Sampetrean O, Saya H, Tominaga T. Convection-enhanced delivery of sulfasalazine
prolongs survival in a glioma stem cell brain tumor model. J Neurooncol. 2018
Jan;136(1):23-31. doi: 10.1007/s11060-017-2621-7. Epub 2017 Sep 19. PubMed PMID:
28929335.
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10: Wang X, Zhang ZY, Arora S, Hughes L, Wang J, Powers D, Christensen J, Lu S,
Kansra V. Effects of Rolapitant Administered Intravenously or Orally on the
Pharmacokinetics of Digoxin (P-glycoprotein Substrate) and Sulfasalazine (Breast
Cancer Resistance Protein Substrate) in Healthy Volunteers. J Clin Pharmacol.
2017 Sep 14. doi: 10.1002/jcph.1005. [Epub ahead of print] PubMed PMID: 28906558.

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