Sulfathiazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000265
  • CAS Number: 72-14-0
  • Molecular Formula: C9H9N3O2S2
  • Molecular Weight: 255.32
  • Purity: ≥95%
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Sulfathiazole(Cat No.:A000265)is a sulfonamide antibiotic used to treat bacterial infections by inhibiting folic acid synthesis, a vital process for bacterial growth and replication. Known for its effectiveness against gram-positive and gram-negative bacteria, it has been widely utilized in both human and veterinary medicine, although its use in humans has decreased due to newer antibiotics. Sulfathiazole is valued in animal health management, particularly for respiratory and gastrointestinal infections. Additionally, it serves as a precursor in organic synthesis and research, contributing to the development of new antimicrobial agents and studies in microbiology.


Catalog Number A000265
CAS Number 72-14-0
Synonyms

72-14-0; Sulphathiazole; Sulfathiazol; Sulfanilamidothiazole; 2-Sulfanilamidothiazole

Molecular Formula C9H9N3O2S2
Purity ≥95%
Target Bacterial
Storage -20°C
IUPAC Name 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide
InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
InChIKey JNMRHUJNCSQMMB-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2
Reference

1: Pontoriero A, Mosconi N, Monti L, Bellú S, Williams PAM, Raimondi M, Lima B,
Feresin GE, Nerli B, Rizzotto M. Synthesis, characterization and biological
studies of a cobalt(III) complex of sulfathiazole. Chem Biol Interact. 2017 Oct
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28987326.
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2: Maham M, Karami-Osboo R. Extraction of Sulfathiazole from Urine Samples Using
Biosynthesized Magnetic Nanoparticles. Iran J Pharm Res. 2017
Spring;16(2):462-470. PubMed PMID: 28979301; PubMed Central PMCID: PMC5603855.

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3: Park K, Kwak IS. Disrupting effects of antibiotic sulfathiazole on
developmental process during sensitive life-cycle stage of Chironomus riparius.
Chemosphere. 2018 Jan;190:25-34. doi: 10.1016/j.chemosphere.2017.09.118. Epub
2017 Sep 26. PubMed PMID: 28972920.
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4: Kwak J, Yoon S, Mahanty B, Kim CG. Redox-mediator-free degradation of
sulfathiazole and tetracycline using Phanerochaete chrysosporium. J Environ Sci
Health A Tox Hazard Subst Environ Eng. 2017 Nov 10;52(13):1211-1217. doi:
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5: Niu XZ, Glady-Croué J, Croué JP. Photodegradation of sulfathiazole under
simulated sunlight: Kinetics, photo-induced structural rearrangement, and
antimicrobial activities of photoproducts. Water Res. 2017 Nov 1;124:576-583.
doi: 10.1016/j.watres.2017.08.019. Epub 2017 Aug 9. PubMed PMID: 28810229.

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6: Kim H, Kim J, Kim M, Hyun S, Moon DH. Sorption of sulfathiazole in the soil
treated with giant Miscanthus-derived biochar: effect of biochar pyrolysis
temperature, soil pH, and aging period. Environ Sci Pollut Res Int. 2017 Apr 28.
doi: 10.1007/s11356-017-9049-7. [Epub ahead of print] PubMed PMID: 28455564.
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7: Gopi SP, Ganguly S, Desiraju GR. A Drug-Drug Salt Hydrate of Norfloxacin and
Sulfathiazole: Enhancement of in Vitro Biological Properties via Improved
Physicochemical Properties. Mol Pharm. 2016 Oct 3;13(10):3590-3594. Epub 2016 Sep
8. PubMed PMID: 27580175.
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8: Keshk SMAS, Ramadan AM, Al-Sehemi AG, Yousef ES, Bondock S. Peculiar behavior
of starch 2,3-dialdehyde towards sulfanilamide and sulfathiazole. Carbohydr
Polym. 2016 Nov 5;152:624-631. doi: 10.1016/j.carbpol.2016.07.061. Epub 2016 Jul
18. PubMed PMID: 27516312.

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9: Velosa AC, Nascimento CAO. Evaluation of sulfathiazole degradation by
persulfate in Milli-Q water and in effluent of a sewage treatment plant. Environ
Sci Pollut Res Int. 2017 Mar;24(7):6270-6277. doi: 10.1007/s11356-016-7036-z.
Epub 2016 Jun 11. PubMed PMID: 27287494.
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10: Mondal S, Mandal SM, Mondal TK, Sinha C. Structural characterization of new
Schiff bases of sulfamethoxazole and sulfathiazole, their antibacterial activity
and docking computation with DHPS protein structure. Spectrochim Acta A Mol
Biomol Spectrosc. 2015;150:268-79. doi: 10.1016/j.saa.2015.05.049. Epub 2015 May
27. PubMed PMID: 26056977.

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