Sulfisoxazole

For research use only, not for therapeutic use.

  • CAT Number: A001159
  • CAS Number: 127-69-5
  • Molecular Formula: C11H13N3O3S
  • Molecular Weight: 267.30
  • Purity: ≥95%
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Sulfisoxazole(Cat No.:A001159)is a sulfonamide antibiotic used to treat bacterial infections by inhibiting the synthesis of folic acid in bacteria, which is essential for their growth and replication. It is effective against a broad range of Gram-positive and Gram-negative bacteria, commonly used to treat urinary tract infections, ear infections, and respiratory infections. Sulfisoxazole is often combined with other antibiotics for enhanced efficacy. Its well-established antibacterial action and low resistance profile make it a reliable choice in treating various bacterial infections, particularly in urinary and respiratory systems.


Catalog Number A001159
CAS Number 127-69-5
Synonyms

NU-445

Molecular Formula C11H13N3O3S
Purity ≥95%
Storage 3 years -20C powder
IUPAC Name 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
InChIKey NHUHCSRWZMLRLA-UHFFFAOYSA-N
SMILES CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
Reference

</br>1:Polymer-free electrospun nanofibers from sulfobutyl ether<sub>7</sub>-beta-cyclodextrin (SBE<sub>7</sub>-β-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole. Yildiz ZI, Celebioglu A, Uyar T.Int J Pharm. 2017 Apr 23. pii: S0378-5173(17)30348-4. doi: 10.1016/j.ijpharm.2017.04.047. [Epub ahead of print] PMID: 28445768 </br>2:Amplified electrochemical sensor employing CuO/SWCNTs and 1-butyl-3-methylimidazolium hexafluorophosphate for selective analysis of sulfisoxazole in the presence of folic acid. Karimi-Maleh H, Amini F, Akbari A, Shojaei M.J Colloid Interface Sci. 2017 Jun 1;495:61-67. doi: 10.1016/j.jcis.2017.01.119. Epub 2017 Feb 3. PMID: 28189110 </br>3:Quantitative determination of sulfisoxazole and its three N-acetylated metabolites using HPLC-MS/MS, and the saturable pharmacokinetics of sulfisoxazole in mice. Oh K, Baek MC, Kang W.J Pharm Biomed Anal. 2016 Sep 10;129:332-8. doi: 10.1016/j.jpba.2016.07.029. Epub 2016 Jul 18. PMID: 27454084 </br>4:Simultaneous determination of N(1)-acetyl sulfisoxazole and its metabolites, and relative bioavailability compare to sulfisoxazole in rats. Kim E, Kang W.J Pharm Biomed Anal. 2016 Sep 10;129:117-20. doi: 10.1016/j.jpba.2016.06.055. Epub 2016 Jul 1. PMID: 27423008 </br>5:Electro-catalytic degradation of sulfisoxazole by using graphene anode. Wang Y, Liu S, Li R, Huang Y, Chen C.J Environ Sci (China). 2016 May;43:54-60. doi: 10.1016/j.jes.2015.08.014. Epub 2015 Dec 2. PMID: 27155409 </br>6:Sorption of sulfisoxazole onto soil–an insight into different influencing factors. Maszkowska J, Białk-Bielińska A, Mioduszewska K, Wagil M, Kumirska J, Stepnowski P.Environ Sci Pollut Res Int. 2015 Aug;22(16):12182-9. doi: 10.1007/s11356-015-4445-3. Epub 2015 Apr 19. PMID: 25893618 </br>7:Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole. Nasr T, Bondock S, Eid S.J Enzyme Inhib Med Chem. 2016;31(2):236-46. doi: 10.3109/14756366.2015.1016514. Epub 2015 Sep 4. PMID: 25815670 </br>8:Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system. Aytac Z, Sen HS, Durgun E, Uyar T.Colloids Surf B Biointerfaces. 2015 Apr 1;128:331-8. doi: 10.1016/j.colsurfb.2015.02.019. Epub 2015 Feb 17. PMID: 25769282 </br>9:Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety. Nasr T, Bondock S, Eid S.Eur J Med Chem. 2014 Sep 12;84:491-504. doi: 10.1016/j.ejmech.2014.07.052. Epub 2014 Jul 16. PMID: 25050881 </br>10:Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole. Soligard HT, Bratlid D, Cao C, Liang A, Nilsen OG.Phytother Res. 2011 Jul;25(7):1068-72. doi: 10.1002/ptr.3402. PMID: 21280114

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