Sulfo DBCO-amine

• CAT Number: I016394
• CAS Number: 2028284-70-8
• Molecular Formula: C₂₁H₂₁N₃O₅S
• Molecular Weight: 427.47
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 3-amino-1-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-1-oxopropane-2-sulfonic acid
• InChI: InChI=1S/C21H21N3O5S/c22-13-19(30(27,28)29)21(26)23-12-11-20(25)24-14-17-7-2-1-5-15(17)9-10-16-6-3-4-8-18(16)24/h1-8,19H,11-14,22H2,(H,23,26)(H,27,28,29)
• InChIKey: LPNNWQSOQIRTRP-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)C(CN)S(=O)(=O)O

Sulfo DBCO-amine (Cat No.:I016394) is a reactive chemical compound commonly used in bioorthogonal chemistry, particularly for labeling and conjugating biomolecules. It contains a dibenzocyclooctyne (DBCO) group, which can undergo a fast and selective click reaction with azides in the presence of copper-free conditions, making it ideal for attaching proteins, peptides, or other biomolecules to surfaces or other molecules. The sulfonate group enhances its solubility in aqueous environments, making Sulfo DBCO-amine useful in applications such as targeted drug delivery, molecular imaging, and protein labeling for research purposes.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562