Sulfo DBCO-PEG4-Maleimide

• CAT Number: I016048
• CAS Number: 2055198-07-5
• Molecular Formula: C₃₉H₄₇N₅O₁₃S
• Molecular Weight: 825.88
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 1-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-[3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-1-oxopropane-2-sulfonic acid
• InChI: InChI=1S/C39H47N5O13S/c45-34(14-18-43-36(47)11-12-37(43)48)40-17-20-55-22-24-57-26-25-56-23-21-54-19-15-35(46)42-27-33(58(51,52)53)39(50)41-16-13-38(49)44-28-31-7-2-1-5-29(31)9-10-30-6-3-4-8-32(30)44/h1-8,11-12,33H,13-28H2,(H,40,45)(H,41,50)(H,42,46)(H,51,52,53)
• InChIKey: QXLOITKOSRDQIZ-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)C(CNC(=O)CCOCCOCCOCCOCCNC(=O)CCN4C(=O)C=CC4=O)S(=O)(=O)O

Sulfo DBCO-PEG4-Maleimide(CAT: I016048) is a versatile, water-soluble heterobifunctional crosslinker designed for efficient bioconjugation. It features a DBCO (Dibenzocyclooctyne) group that enables copper-free click chemistry through strain-promoted azide-alkyne cycloaddition (SPAAC) and a maleimide group that selectively reacts with thiol groups on cysteine residues in proteins or peptides. The PEG4 (polyethylene glycol) spacer enhances solubility and reduces steric hindrance, improving reaction efficiency and biocompatibility. This reagent is widely used in antibody-drug conjugate (ADC) synthesis, protein labeling, and biomolecular imaging, providing a robust tool for creating stable and site-specific bioconjugates in biomedical research.