Sulfo DBCO-PEG4-Maleimide TEA

• CAT Number: I041012
• Molecular Formula: C45H62N6O13S
• Molecular Weight: 927.07
• Purity: ≥95%
• Synonyms: 1-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-[3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-1-oxopropane-2-sulfonic acid;N,N-diethylethanamine
• InChI: InChI=1S/C39H47N5O13S.C6H15N/c45-34(14-18-43-36(47)11-12-37(43)48)40-17-20-55-22-24-57-26-25-56-23-21-54-19-15-35(46)42-27-33(58(51,52)53)39(50)41-16-13-38(49)44-28-31-7-2-1-5-29(31)9-10-30-6-3-4-8-32(30)44;1-4-7(5-2)6-3/h1-8,11-12,33H,13-28H2,(H,40,45)(H,41,50)(H,42,46)(H,51,52,53);4-6H2,1-3H3
• InChIKey: MTAIVIDQGSMDTM-UHFFFAOYSA-N
• SMILES: CCN(CC)CC.C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)C(CNC(=O)CCOCCOCCOCCOCCNC(=O)CCN4C(=O)C=CC4=O)S(=O)(=O)O

Sulfo DBCO-PEG4-Maleimide TEA(CAT: I041012) is a versatile linker molecule designed for bioconjugation applications, specifically in the development of targeted therapies and imaging agents. The sulfonated DBCO (dibenzocyclooctyne) group enables efficient copper-free click chemistry reactions with azide-containing biomolecules, while the maleimide group allows for covalent attachment to thiol groups, such as those present in cysteine residues of proteins or peptides. The PEG4 spacer provides enhanced solubility and flexibility, facilitating the formation of stable conjugates without compromising the activity of the bioactive components. Sulfo DBCO-PEG4-Maleimide TEA is ideal for generating conjugates for drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.