For research use only. Not for therapeutic Use.
Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker. Sulfo-NHS-Acetate sodium can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I041100 |
| CAS Number | 221222-61-3 |
| Synonyms | sodium;1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonate |
| Molecular Formula | C6H6NNaO7S |
| Purity | ≥95% |
| InChI | InChI=1S/C6H7NO7S.Na/c1-3(8)14-7-5(9)2-4(6(7)10)15(11,12)13;/h4H,2H2,1H3,(H,11,12,13);/q;+1/p-1 |
| InChIKey | VGYOVKDAMGIIJU-UHFFFAOYSA-M |
| SMILES | CC(=O)ON1C(=O)CC(C1=O)S(=O)(=O)[O-].[Na+] |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
