Sulfo-TAG NHS ester disodium

• CAT Number: I040078
• CAS Number: 482618-42-8
• Molecular Formula: C43H39N7Na2O16RuS4
• Molecular Weight: 1185.12
• Purity: ≥95%
• Synonyms: disodium;(2,5-dioxopyrrolidin-1-yl) 4-[2-(4-methylpyridin-2-yl)pyridin-4-yl]butanoate;ruthenium(2+);[2-[4-(sulfonatomethyl)pyridin-2-yl]pyridin-4-yl]methanesulfonate
• InChI: InChI=1S/C19H19N3O4.2C12H12N2O6S2.2Na.Ru/c1-13-7-9-20-15(11-13)16-12-14(8-10-21-16)3-2-4-19(25)26-22-17(23)5-6-18(22)24;2*15-21(16,17)7-9-1-3-13-11(5-9)12-6-10(2-4-14-12)8-22(18,19)20;;;/h7-12H,2-6H2,1H3;2*1-6H,7-8H2,(H,15,16,17)(H,18,19,20);;;/q;;;2*+1;+2/p-4
• InChIKey: GPSOIZKEYLTPJQ-UHFFFAOYSA-J
• SMILES: CC1=CC(=NC=C1)C2=NC=CC(=C2)CCCC(=O)ON3C(=O)CCC3=O.C1=CN=C(C=C1CS(=O)(=O)[O-])C2=NC=CC(=C2)CS(=O)(=O)[O-].C1=CN=C(C=C1CS(=O)(=O)[O-])C2=NC=CC(=C2)CS(=O)(=O)[O-].[Na+].[Na+].[Ru+2]

Sulfo-TAG NHS Ester Disodium is (Cat No.: I040078) a highly water-soluble chemiluminescent labeling reagent, designed for bioconjugation and immunoassays. The N-hydroxysuccinimide (NHS) ester enables efficient conjugation to primary amines on proteins, peptides, and antibodies, making it ideal for ELISA, Western blotting, and biomarker detection. Its sulfonated structure enhances aqueous stability and solubility, ensuring high labeling efficiency with minimal background interference. Widely used in diagnostics and drug discovery, it provides sensitive, quantitative detection for protein-protein interactions and cellular signaling studies.

Reference

[1]. Kanghoon Lee, et al. Analysis of ocular fluid in patients with ranibizumab-recalcitrant neovascular age-related macular degeneration who have serum anti-ranibizumab antibodies. Graefes Arch Clin Exp Ophthalmol. 2023, 261, 12.
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