For research use only. Not for therapeutic Use.
Sulopenem Etzadroxil（Cat No.:I009482）is a potent oral antibiotic designed to combat a range of bacterial infections, particularly those resistant to traditional treatments. As a novel penem antibiotic, it works by inhibiting bacterial cell wall synthesis, showing efficacy against both Gram-positive and Gram-negative bacteria. Sulopenem Etzadroxil is effective for treating infections such as urinary tract infections (UTIs) and respiratory infections, providing a viable oral option where intravenous antibiotics were once required. Its stability and broad-spectrum activity make it valuable in the fight against antibiotic resistance.
| Catalog Number | I009482 |
| CAS Number | 1000296-70-7 |
| Synonyms | Sulopenem etzadroxil; PF-03709270; PF03709270; PF 03709270; PF-3709270; PF3709270; PF 3709270.;((2-ethylbutanoyl)oxy)methyl (5R,6S)-6-((R)-1-hydroxyethyl)-3-(((3S)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carb |
| Molecular Formula | C19H27NO7S3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 2-ethylbutanoyloxymethyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(1R,3S)-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate |
| InChI | InChI=1S/C19H27NO7S3/c1-4-11(5-2)17(23)26-9-27-18(24)14-19(28-12-6-7-30(25)8-12)29-16-13(10(3)21)15(22)20(14)16/h10-13,16,21H,4-9H2,1-3H3/t10-,12+,13+,16-,30-/m1/s1 |
| InChIKey | NBPVNGWRLGHULH-CSOWVJSESA-N |
| SMILES | CCC(CC)C(=O)OCOC(=O)C1=C(S[C@H]2N1C(=O)[C@@H]2[C@@H](C)O)S[C@H]3CC[S@@](=O)C3 |
| Reference | </br> 1:Kosowska-Shick K, Ednie LM, McGhee P, Appelbaum PC. Comparative antipneumococcal activities of sulopenem and other drugs. Antimicrob Agents Chemother. 2009 Jun;53(6):2239-47. doi: 10.1128/AAC.01531-08. PubMed PMID: 19307366; PubMed Central PMCID: PMC2687188.</br> 2:Wujcik CE, Kadar EP. Reduction of in-source collision-induced dissociation and thermolysis of sulopenem prodrugs for quantitative liquid chromatography/electrospray ionization mass spectrometric analysis by promoting sodium adduct formation. Rapid Commun Mass Spectrom. 2008 Oct;22(20):3195-206. doi: 10.1002/rcm.3722. PubMed PMID: 18803331. |
