Sulpiride

• CAT Number: I001991
• CAS Number: 15676-16-1
• Molecular Formula: C15H23N3O4S
• Molecular Weight: 341.42
• Purity: ≥95%
• Synonyms: (R)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-methoxy-5-sulfamoylbenzamide
• Target: Dopamine Receptor
• Solubility: DMSO:33mg/mL
• Storage: Store at RT
• IUPAC Name: N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
• InChI: InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
• InChIKey: BGRJTUBHPOOWDU-UHFFFAOYSA-N
• SMILES: CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC

Sulpiride (CAT: I001991) is a benzamide-class atypical antipsychotic drug that acts as a selective antagonist of the D2 dopamine receptors. It is primarily utilized in the treatment of psychosis associated with schizophrenia and major depressive disorder. Additionally, sulpiride can be prescribed in low doses to alleviate symptoms of anxiety and mild depression. By blocking the D2 receptors, sulpiride helps regulate dopamine activity in the brain, which plays a role in managing symptoms of various mental health conditions.

Reference

1:Possible role of organic cation transporters in the distribution of [11C]sulpiride, a dopamine D2 receptor antagonist. Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y.J Pharm Sci. 2017 May 9. pii: S0022-3549(17)30359-3. doi: 10.1016/j.xphs.2017.05.006. [Epub ahead of print] PMID: 28499878
2:Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects. Skrobecki P, Chmielińska A, Bonarek P, Stepien P, Wisniewska-Becker A, Dziedzicka-Wasylewska M, Polit A.ACS Chem Neurosci. 2017 Apr 12. doi: 10.1021/acschemneuro.7b00057. [Epub ahead of print] PMID: 28375612
3:Time to Discontinuation of Second-Generation Antipsychotics Versus Haloperidol and Sulpiride in People With Schizophrenia: A Naturalistic, Comparative Study. Chan HY, Pan YJ, Chen JJ, Chen CH.J Clin Psychopharmacol. 2017 Feb;37(1):13-20. doi: 10.1097/JCP.0000000000000623. PMID: 27977467
4:Brain histamine depletion enhances the behavioural sequences complexity of mice tested in the open-field: Partial reversal effect of the dopamine D2/D3 antagonist sulpiride. Santangelo A, Provensi G, Costa A, Blandina P, Ricca V, Crescimanno G, Casarrubea M, Passani MB.Neuropharmacology. 2017 Feb;113(Pt A):533-542. doi: 10.1016/j.neuropharm.2016.11.007. Epub 2016 Nov 8. PMID: 27833003
5:Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation. Bollmann AF, Seitz W, Prasse C, Lucke T, Schulz W, Ternes T.J Hazard Mater. 2016 Dec 15;320:204-215. doi: 10.1016/j.jhazmat.2016.08.022. Epub 2016 Aug 8. PMID: 27544733
6:Development of a novel l-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability. Kim DS, Kim DW, Kim KS, Choi JS, Seo YG, Youn YS, Oh KT, Yong CS, Kim JO, Jin SG, Choi HG.Colloids Surf B Biointerfaces. 2016 Nov 1;147:250-7. doi: 10.1016/j.colsurfb.2016.08.010. Epub 2016 Aug 8. PMID: 27518457
7:Comparison of solvent-wetted and kneaded l-sulpiride-loaded solid dispersions: Powder characterization and in vivo evaluation. Kim DS, Choi JS, Kim DW, Kim KS, Seo YG, Cho KH, Kim JO, Yong CS, Youn YS, Lim SJ, Jin SG, Choi HG.Int J Pharm. 2016 Sep 10;511(1):351-8. doi: 10.1016/j.ijpharm.2016.07.006. Epub 2016 Jul 7. PMID: 27397868
8:Metformin-induced acute dystonia in a schizophrenic patient treated with sulpiride and clozapine. Chen WH, Huang WL, Hsieh MH.Psychiatry Clin Neurosci. 2016 Aug;70(8):362-3. doi: 10.1111/pcn.12405. Epub 2016 Jul 14. No abstract available. PMID: 27193328
9:In Vivo Evaluation of a PEO-Gellan Gum Semi-Interpenetrating Polymer Network for the Oral Delivery of Sulpiride. Hoosain FG, Choonara YE, Kumar P, Tomar LK, Tyagi C, du Toit LC, Pillay V.AAPS PharmSciTech. 2017 Apr;18(3):654-670. doi: 10.1208/s12249-016-0538-7. Epub 2016 May 16. PMID: 27184677
10:Effects of Sulpiride on True and False Memories of Thematically Related Pictures and Associated Words in Healthy Volunteers. Guarnieri RV, Ribeiro RL, de Souza AA, Galduróz JC, Covolan L, Bueno OF.Front Psychiatry. 2016 Mar 18;7:28. doi: 10.3389/fpsyt.2016.00028. eCollection 2016. PMID: 27047394 Free PMC Article