For research use only. Not for therapeutic Use.
Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.<br>Sumatriptan displays the highest affinity for 5-HT1D (Ki = 17 nM) and 5-HT1B (Ki = 27 nM) binding sites and is slightly less potent at 5-HT1A binding sites (Ki = 100 nM).<br>Sumatriptan at a clinically relevant dose (100 mg/kg, s.c.) leads to a significant reduction of the mechanical allodynia-like behaviour on both the injured and the contralateral sides (peak-effects 6.3 g and 4.4 g, respectively) in a rat model of trigeminal neuropathic pain.
| Catalog Number | A000764 |
| CAS Number | 103628-48-4 |
| Synonyms | GR 43175 |
| Molecular Formula | C14H21N3O2S • C4H6O4 |
| Purity | ≥95% |
| Target | 5-HT Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| InChIKey | PORMUFZNYQJOEI-UHFFFAOYSA-N |
