Sunitinib-d10

• CAT Number: R006047
• CAS Number: 1126721-82-1
• Molecular Formula: C22H27FN4O2
• Molecular Weight: 408.54
• Purity: ≥95%
• Synonyms: N-[2-(Diethyl-d10)aminoethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; Sutent-d10; SU-11248-d10
• Target: Cell Cycle/DNA Damage
• Storage: -20°C
• IUPAC Name: N-[2-[bis(1,1,2,2,2-pentadeuterioethyl)amino]ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
• InChI: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-/i1D3,2D3,5D2,6D2
• InChIKey: WINHZLLDWRZWRT-BLSNYXODSA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])N(CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C)C([2H])([2H])C([2H])([2H])[2H]

Sunitinib-d10（Cat No.:R006047） is a deuterated version of sunitinib, a tyrosine kinase inhibitor used in cancer treatment, featuring ten deuterium atoms. This isotopic enrichment enhances its analytical detection and quantification, particularly in pharmacokinetic and metabolic studies. It facilitates a deeper understanding of sunitinib’s absorption, distribution, metabolism, and excretion (ADME) processes, critical for optimizing therapeutic efficacy and minimizing side effects. Sunitinib-d10 is invaluable for developing personalized medicine strategies and improving dosage regimens in oncology, aiding researchers and clinicians in tailoring cancer treatments to individual patient needs.