Sunitinib free base

For research use only. Not for therapeutic Use.

  • CAT Number: A000114
  • CAS Number: 557795-19-4
  • Molecular Formula: C22H27FN4O2
  • Molecular Weight: 398.48
  • Purity: ≥95%
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Sunitinib Free Base(Cat No.:A000114)is a multi-targeted tyrosine kinase inhibitor that blocks several receptors, including vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and c-Kit. It is primarily used in the treatment of advanced renal cell carcinoma, gastrointestinal stromal tumors (GIST), and pancreatic neuroendocrine tumors. By inhibiting these key receptors, sunitinib disrupts tumor growth, angiogenesis, and metastasis, making it an effective anticancer agent. Its broad spectrum of activity against multiple signaling pathways has established sunitinib as a crucial therapeutic option for managing various solid tumors.


Catalog Number A000114
CAS Number 557795-19-4
Synonyms

U11248

Molecular Formula C22H27FN4O2
Purity ≥95%
Target PDGFR
Solubility >19.9mg/mL in DMSO
Storage Store at -20°C
IUPAC Name N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
Reference

1: Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib
efficacy and future clinical development. Nat Rev Drug Discov. 2007
Sep;6(9):734-45. Review. PubMed PMID: 17690708.
<br>

2: MacIntyre J. Pharmacologic application of sunitinib malate in the management
of gastrointestinal stromal tumors. Clin J Oncol Nurs. 2007 Apr;11(2):237-41.
Review. PubMed PMID: 17573273.
<br>

3: Reddy K. Phase III study of sunitinib malate (SU11248) versus interferon-alpha
as first-line treatment in patients with metastatic renal cell carcinoma. Clin
Genitourin Cancer. 2006 Jun;5(1):23-5. Review. PubMed PMID: 16859575.
<br>

4: Cabebe E, Wakelee H. Sunitinib: a newly approved small-molecule inhibitor of
angiogenesis. Drugs Today (Barc). 2006 Jun;42(6):387-98. Review. PubMed PMID:
16845442.

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