For research use only. Not for therapeutic Use.
Supinoxin (RX-5902)（Cat No.:I009651）is a small molecule inhibitor that targets the protein inhibitor of κB kinase (IKK), which plays a key role in the NF-κB signaling pathway. This pathway regulates inflammation, immune responses, and cell survival. Supinoxin has shown promise as an anti-inflammatory and anticancer agent, as it can block the NF-κB pathway, leading to reduced tumor growth, metastasis, and inflammatory responses. It has been investigated for use in treating various cancers, including solid tumors, and autoimmune diseases. Clinical studies are ongoing to assess its safety, efficacy, and potential therapeutic benefits.
| CAS Number | 888478-45-3 |
| Synonyms | Supinoxin; RX5902; RX5902; RX 5902.;4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide |
| Molecular Formula | C22H24FN5O4 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide |
| InChI | InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29) |
| InChIKey | KAKPGJJRYRYSTP-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1)N2CCN(CC2)C(=O)NC3=NC4=C(C=CC(=C4)F)N=C3OC)OC |
| Reference | </br>1: Kost GC, Yang MY, Li L, Zhang Y, Liu CY, Kim DJ, Ahn CH, Lee YB, Liu ZR. A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine (RX-5902),Interferes with β-Catenin Function through Y593 phospho-p68RNA Helicase. J Cell Biochem. 2015 Feb 3. doi: 10.1002/jcb.25113. [Epub ahead of print] PubMed PMID: 25649741. |
