Suprafenacine

• CAT Number: I014695
• CAS Number: 1477482-50-0
• Molecular Formula: C16H18N4O
• Molecular Weight: 282.34
• Purity: ≥95%
• IUPAC Name: N-[(E)-(4-methylphenyl)methylideneamino]-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide
• InChI: InChI=1S/C16H18N4O/c1-11-6-8-12(9-7-11)10-17-20-16(21)15-13-4-2-3-5-14(13)18-19-15/h6-10H,2-5H2,1H3,(H,18,19)(H,20,21)/b17-10+
• SMILES: CC1=CC=C(C=C1)/C=N/NC(=O)C2=NNC3=C2CCCC3

Destabilizer of microtubules (IC50 value 0.38 µM for microtubule polymerization inhibition) that causes cell cycle arrest in the G2/M phase and cell death by apoptosis. Suprafenacine (SRF) was found to selectively inhibit cancer cell proliferation (IC50 values 83 – 381 nM in various cancer cell lines) and was effective against drug-resistant cancer cells by virtue of its ability to bypass the multidrug resistance transporter P-glycoprotein (P-gp).

Reference

B.H. Choi et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One. 2014 Oct 29;9(10):e110955.