For research use only. Not for therapeutic Use.
Suramin（Cat No.:I001761） is a versatile compound with various pharmacological activities. It acts as a reversible, competitive inhibitor of protein tyrosine phosphatases (PTPases). It also exhibits potent inhibitory effects on sirtuins, including SirT1, SirT2, and SirT5. Suramin competes with reverse transcriptase and inhibits DNAtopoisomeraseII. It shows potent inhibition of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). Additionally, it inhibits IP5K and possesses antiparasitic, antitumor, and antiangiogenic properties. With its broad range of activities, suramin holds promise for various therapeutic applications in the treatment of diseases including cancer, parasitic infections, and viral infections.
| Catalog Number | I001761 |
| CAS Number | 145-63-1 |
| Molecular Formula | C51H40N6O23S6 |
| Purity | ≥95% |
| Target | Epigenetics |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid |
| InChI | InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) |
| InChIKey | FIAFUQMPZJWCLV-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C |
| Reference | <p style=/line-height:25px/> |
