Surfen dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I012350
  • CAS Number: 5424-37-3
  • Molecular Formula: C21H22Cl2N6O
  • Molecular Weight: 445.34
  • Purity: ≥95%
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Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].


Catalog Number I012350
CAS Number 5424-37-3
Synonyms

1,3-bis(4-amino-2-methylquinolin-6-yl)urea;dihydrochloride

Molecular Formula C21H22Cl2N6O
Purity ≥95%
InChI InChI=1S/C21H20N6O.2ClH/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);2*1H
InChIKey GKQYGRWQCWWSHN-UHFFFAOYSA-N
SMILES CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N)N.Cl.Cl
Reference

[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.
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