Survodutide TFA

• CAT Number: I040978
• Molecular Formula: C192H289N47O61.xC2HF3OC2
• Molecular Weight: 4231.62 (free base)
• Purity: ≥95%
• Target: Glucagon-Like Peptide 1 (GLP-1) Receptor

Survodutide TFA(CAT: I040978) (also known as BI 456906 TFA) is a 29-amino-acid acylated peptide, functioning as a potent and selective dual agonist of the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R). In CHO-K1 cells, it exhibits EC₅₀ values of 0.52 nM for GCGR and 0.33 nM for GLP-1R. The peptide is modified with a C18 fatty acid, enhancing its pharmacokinetic properties. Survodutide TFA has demonstrated significant anti-obesity effects by increasing energy expenditure and reducing food intake. It is currently under investigation for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) and has received Breakthrough Therapy Designation from the China National Medical Products Administration (NMPA).