SV40 large T antigen NLS

• CAT Number: I046344
• CAS Number: 163815-24-5
• Molecular Formula: C58H104N20O18S
• Molecular Weight: 1401.63
• Purity: ≥95%

SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.
SV40 large tumor-antigen (T-ag) nuclear import is enhanced by the protein kinase CK2 (CK2) site (Ser111Ser112) flanking the nuclear localization sequence (NLS)[1]. T-ag NLS can enhance nuclear import, despite the fact that PK-C has been shown to inhibit nuclear import of proteins such as lamin B2[2].

Reference

[1]. Xiao CY, et al. Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large T-antigen NLS by importin: effect of conformation. FEBS Lett. 1998 Dec 4;440(3):297-301.
 [Content Brief]

[2]. Xiao CY, et al. An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import. FEBS Lett. 1998 Oct 9;436(3):313-7.
 [Content Brief]