For research use only. Not for therapeutic Use.
SW033291(CAT: I003602) is a potent small-molecule inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with a Ki of 0.1 nM. By inhibiting 15-PGDH, it prevents the degradation of prostaglandin E2 (PGE2), thereby elevating PGE2 levels in bone marrow and other tissues. This mechanism enhances tissue repair and regeneration by promoting stem cell proliferation and improving hematopoietic recovery. SW033291 is particularly significant in regenerative medicine and hematology research, where it is used to investigate the therapeutic potential of PGE2 modulation in wound healing, bone marrow recovery, and other conditions requiring enhanced tissue repair. Its specificity and efficacy make it a valuable tool for advancing prostaglandin-related therapies.
| Catalog Number | I003602 |
| CAS Number | 459147-39-8 |
| Synonyms | 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine |
| Molecular Formula | C₂₁H₂₀N₂OS₃ |
| Purity | ≥95% |
| Target | 15-PGDH |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.1 nM(Ki) [1] |
| IUPAC Name | 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine |
| InChI | InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3 |
| InChIKey | LCYAYKSMOVLVRL-UHFFFAOYSA-N |
| SMILES | CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N |
