For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.<br>IC50 value: 0.1 nM(Ki) [1]<br>Target: 15-PGDH<br>in vitro: SW033291 inhibition of 15-PGDH was noncompetitive versus PGE2 over concentrations up to 40 μM PGE2. SW033291 also demonstrated selective high-affinity interaction with 15-PGDH in thermal denaturation assays. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with 50% of maximal stimulation (EC50) at ~75 nM [1].<br>in vivo: mice injected with SW033291 closely phenocopied 15-PGDH knockout mice, with 10 mg per kg of weight (mg/kg) SW033291 inducing a twofold increase in PGE2 levels in bone marrow, colon, lung, and liver. Mice injected with SW033291 at 20 mg/kg daily for 7 days showed equivalent daily weights and activity as mice injected with vehicle-control and showed no adverse changes in blood counts or serum chemistry [1].</p>
| Catalog Number | I003602 |
| CAS Number | 459147-39-8 |
| Synonyms | 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine |
| Molecular Formula | C₂₁H₂₀N₂OS₃ |
| Purity | ≥95% |
| Target | 15-PGDH |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.1 nM(Ki) [1] |
| InChI | InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3 |
| InChIKey | LCYAYKSMOVLVRL-UHFFFAOYSA-N |
| SMILES | CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N |
| Reference | <p style=/line-height:25px/> </p> |
