SW-044248

• CAT Number: I003909
• CAS Number: 522650-83-5
• Molecular Formula: C22H23N5O2S
• Molecular Weight: 421.519
• Purity: ≥95%
• Target: Topoisomerase
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IUPAC Name: 2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(2-methoxyphenyl)butanamide
• InChI: InChI=1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
• InChIKey: PEVRGVRHMMZNGI-UHFFFAOYSA-N
• SMILES: CCC(C(=O)NC1=CC=CC=C1OC)SC2=NC3=C(C4=CC=CC=C4N3CC)N=N2

SW-044248 (CAT: I003909) is a promising noncanonical topoisomerase 1 (Top1) inhibitor that exhibits a distinct pattern of selective toxicity against non-small cell lung cancer (NSCLC) cells. This compound effectively disrupts Top1-mediated DNA processes in a unique manner, making it a potential candidate for targeted therapy against NSCLC. SW-044248’s specific cytotoxicity towards NSCLC cells suggests its potential utility in the development of innovative strategies for treating this type of cancer, highlighting its significance as a novel therapeutic agent in oncology research.

Reference

[1]. Zubovych IO, et al. A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Ther. 2016 Jan;15(1):23-36.
[2]. Kim HS, et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct 24;155(3):552-66.