For research use only. Not for therapeutic Use.
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].
| Catalog Number | R067037 |
| CAS Number | 420092-79-1 |
| Synonyms | 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide |
| Molecular Formula | C16H11ClN2O5S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H |
| InChIKey | JDYDEJYIVZNWQU-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CC=C2O)NS(=O)(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-] |
| Reference | [1]. Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288(27):19673-84. [2]. José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15(2):3253-61. |
