For research use only. Not for therapeutic Use.
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH[1].
| Catalog Number | I018086 |
| CAS Number | 2376322-12-0 |
| Synonyms | 4-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]butanoic acid |
| Molecular Formula | C19H15Cl2NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H15Cl2NO3/c20-14-10-9-13(11-15(14)21)18-19(12-5-2-1-3-6-12)25-16(22-18)7-4-8-17(23)24/h1-3,5-6,9-11H,4,7-8H2,(H,23,24) |
| InChIKey | UIADWSXPNFQQCZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=C(N=C(O2)CCCC(=O)O)C3=CC(=C(C=C3)Cl)Cl |
| Reference | [1]. Kramer JS, et al. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. J Med Chem. 2019 Aug 22. |
