For research use only. Not for therapeutic Use.
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice[1][2].
SY-640 inhibits the number of liver-infiltrating cells and attenuates the increased expression of leukocyte function-associated antigen-1 on these cells[1].
SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect[1].
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640[2].
| Catalog Number | I045664 |
| CAS Number | 168705-70-2 |
| Synonyms | N-(1,3-benzodioxol-5-ylmethyl)-N-methylacetamide |
| Molecular Formula | C11H13NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H13NO3/c1-8(13)12(2)6-9-3-4-10-11(5-9)15-7-14-10/h3-5H,6-7H2,1-2H3 |
| InChIKey | JIWDGIYBLGMPRV-UHFFFAOYSA-N |
| SMILES | CC(=O)N(C)CC1=CC2=C(C=C1)OCO2 |
| Reference | [1]. Y Tanaka, et al. Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. Arch Int Pharmacodyn Ther. Mar-Apr 1995;329(2):319-30. [2]. P F Li, et al. [Inhibitory effect of 2-(N-acetyl-methyl amino)-3′,4′-methylenedioxyacetyl-aminophene(SY-640) on covalent binding of carcinogenic benzo(a)pyrene with mouse hepatocyte nuclear DNA]. Yao Xue Xue Bao. 1997 Sep;32(9):663-8. |
