SY-LB-57

• CAT Number: I043308
• CAS Number: 2253719-35-4
• Molecular Formula: C16H13N3O
• Molecular Weight: 263.29
• Purity: ≥95%
• Synonyms: 2-(5-methoxy-1H-indol-2-yl)-1H-benzimidazole
• InChI: InChI=1S/C16H13N3O/c1-20-11-6-7-12-10(8-11)9-15(17-12)16-18-13-4-2-3-5-14(13)19-16/h2-9,17H,1H3,(H,18,19)
• InChIKey: CKMZAHNTGUKLJF-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)NC(=C2)C3=NC4=CC=CC=C4N3

SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension[1].
SY-LB-57 (0.01-1000 μM, 24 h) can significantly induce cell proliferation at concentrations below 10 µM with an IC50 value of 807.93 µM in C2C12 cells[1].
SY-LB-57 (0.01-10 μM, 15-30 min) increases the phosphorylation of Smad protein and promotes p-Smad nuclear translocation while activates the PI3K/Akt pathway and induces cytoplasmic localization of p-Akt[1].
SY-LB-57 (0.01-10 μM, 24 h) can induce cell cycle shift towards proliferation[1].

Reference

[1]. Sheyda Najafi, et al. Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling. Sci Rep. 2022 Jul 15;12(1):12146.
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