Syk-IN-1

• CAT Number: I036889
• CAS Number: 1491150-77-6
• Molecular Formula: C18H22N8O
• Molecular Weight: 366.42
• Purity: ≥95%
• Synonyms: 3-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-7-ylamino)-1,2,4-triazine-6-carboxamide
• InChI: InChI=1S/C18H22N8O/c19-11-5-1-2-6-12(11)23-18-24-17(15(16(20)27)25-26-18)22-13-7-3-4-10-8-9-21-14(10)13/h3-4,7-9,11-12,21H,1-2,5-6,19H2,(H2,20,27)(H2,22,23,24,26)/t11-,12+/m0/s1
• InChIKey: FPQNRXITKTZFMF-NWDGAFQWSA-N
• SMILES: C1CCC(C(C1)N)NC2=NC(=C(N=N2)C(=O)N)NC3=CC=CC4=C3NC=C4

Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM[1].

Reference

[1]. Thoma G, et al. Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg Med Chem Lett. 2015;25(20):4642-4647.
 [Content Brief]