SYM 2081

• CAT Number: R002858
• CAS Number: 31137-74-3
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.16
• Purity: ≥95%
• Synonyms: (2S,4R)-2-amino-4-methylpentanedioic acid
• InChI: InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
• InChIKey: KRKRAOXTGDJWNI-DMTCNVIQSA-N
• SMILES: CC(CC(C(=O)O)N)C(=O)O

SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively[1].

Reference

[1]. Lee JY, et al. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150(4):546-57.
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