For research use only. Not for therapeutic Use.
SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents[1][2].
| Catalog Number | I002269 |
| CAS Number | 173952-44-8 |
| Synonyms | 8-(4-aminophenyl)-5-methyl-N-propyl-5H-[1,3]dioxolo[4,5-g]phthalazine-6-carboxamide |
| Molecular Formula | C20H22N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H22N4O3/c1-3-8-22-20(25)24-12(2)15-9-17-18(27-11-26-17)10-16(15)19(23-24)13-4-6-14(21)7-5-13/h4-7,9-10,12H,3,8,11,21H2,1-2H3,(H,22,25) |
| InChIKey | OFUDZKKOKPGXOH-UHFFFAOYSA-N |
| SMILES | CCCNC(=O)N1C(C2=CC3=C(C=C2C(=N1)C4=CC=C(C=C4)N)OCO3)C |
| Reference | [1]. Bleakman D, et, al. Kainate receptor agonists, antagonists and allosteric modulators. Curr Pharm Des. 2002;8(10):873-85. [2]. Welch NC, et al. Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent current. Neuropharmacology. 2008 Dec;55(7):1165-71. |
