SZL P1-41

• CAT Number: I002708
• CAS Number: 222716-34-9
• Molecular Formula: C24H24N2O3S
• Molecular Weight: 420.52
• Purity: ≥95%
• Synonyms: 3-(benzo[d]thiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
• Target: E3 Ligase
• Solubility: 10 mM in DMSO
• Storage: Room Temperature
• IUPAC Name: 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)chromen-4-one
• InChI: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
• InChIKey: JKIXLEKBXHMXTN-UHFFFAOYSA-N
• SMILES: CCC1=CC2=C(C(=C1O)CN3CCCCC3)OC=C(C2=O)C4=NC5=CC=CC=C5S4

SZLP1-41（Cat No.:I002708） is a highly specific inhibitor of Skp2, a protein involved in cell cycle regulation. By binding to the F-box domain of Skp2, SZLP1-41 prevents the association of Skp2 with Skp1 and inhibits the formation of the Skp2SCF complex. Similar to Skp2 deficiency, SZLP1-41 promotes p27-mediated apoptosis and senescence while hindering Akt-driven glycolysis. Due to these effects, SZLP1-41 exhibits antitumor activity, making it a potential candidate for targeted cancer therapies aimed at inhibiting Skp2 function.

Reference

[1]. Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.