For research use only. Not for therapeutic Use.
T-26c (Cat No.:I012012) is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 value of 6.9 pM, 2600 times more selective than other related metalloenzymes.If you need, please feel free to contact us, we will reply to you within 24 hours.
| Catalog Number | I012012 |
| CAS Number | 869296-13-9 |
| Synonyms | T-26c, T26c, T 26c;4-(((2-((3-methoxybenzyl)carbamoyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)methoxy)methyl)benzoic acid |
| Molecular Formula | C24H21N3O6S |
| Purity | ≥95% |
| Target | MMP |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid |
| InChI | InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28) |
| InChIKey | CDQRIIUMNLMHRH-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC(=C1)CNC(=O)C2=NC3=C(C(=CS3)COCC4=CC=C(C=C4)C(=O)O)C(=O)N2 |
| Reference | </br>1: Florent M, Noël T, Ruprich-Robert G, Da Silva B, Fitton-Ouhabi V, Chastin C, Papon N, Chapeland-Leclerc F. Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. Antimicrob Agents Chemother. 2009 Jul;53(7):2982-90. doi: 10.1128/AAC.00880-08. Epub 2009 May 4. PubMed PMID: 19414575; PubMed Central PMCID: PMC2704628.</br> |
